RABBIT ANTIBODIES TO STREPTOCOCCAL CARBOHYDRATES
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چکیده
منابع مشابه
Rabbit Antibodies to Streptococcal Carbohydrates
In a search for possible genetic factors which may influence the immune response to the streptococcal carbohydrates, over 100 rabbits have been immunized with streptococcal vaccines, and representative examples of high and low response pairs mated. The concentration of precipitins to the group-specific carbohydrates has been measured in the antisera following primary intravenous immunization wi...
متن کاملRelationships between Relative Binding Affinity and Electrophoretic Behavior of Rabbit Antibodies to Streptococcal Carbohydrates
After repeated intravenous injections with Group C streptococcal vaccine, most rabbit antisera were shown to contain one or more IgG antibody components, as revealed by microzone electrophoresis. A procedure for the fractionation of multiple IgG antibody components from such streptococcal antisera is described. Separation is achieved on the basis of differences in relative binding affinities of...
متن کاملThe Inheritance of Individual Antigenic Specificities of Rabbit Antibodies to Streptococcal Carbohydrates
The inheritance of individual antigenic specificities (IAS) of rabbit antibodies to the Group C streptococcal carbohydrate was demonstrated in a selectively bred rabbit family. The IAS of the antibodies from 3 proband rabbits were also observed in the Group C antibodies in as many as 7 out of 42 related rabbits, but in none of the Group C antibodies from 48 unrelated rabbits, Immunodiffusion an...
متن کاملThe Individual Antigenic Specificity of Antibodies to Streptococcal Carbohydrates
Although a single electrophoretically uniform antibody component with specificity for the group carbohydrate may comprise the bulk of the gamma-globulin in rabbits immunized with streptococcal vaccines, this is not always the case. Not infrequently, electrophoresis may reveal multiple antibody components. Nevertheless, it has been feasible by various preparative procedures to isolate from a sin...
متن کاملIdiotypic Specificity of Rabbit Antibodies to Streptococcal Group Polysaccharides
Anti-idiotypic antisera against six restricted rabbit streptococcal group specific antibodies have been raised in rabbits matched for allotypes. All these antisera reacted specifically with their homologous idiotypes on double-diffusion tests in agarose gel. In addition, they showed a high incidence of cross-specificities with group-specific hyperimmune sera induced in both closely related and ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1969
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.129.4.809